gonadotropin n : hormone secreted by the anterior pituitary gland and placenta; stimulates the gonads and controls reproductive activity [syn: gonadotrophin, gonadotropic hormone, gonadotrophic hormone]
- gonadotrophin (Britain)
- Italian: gonadotropina
Gonadotropins are protein hormones secreted by gonadotrope cells of the pituitary gland of vertebrates.
Gonadotropin is sometimes abbreviated Gn. The British spelling is gonadotrophin.
TypesThe two principal gonadotropins are luteinizing hormone (LH) and follicle stimulating hormone (FSH). Both hormones consist of two peptide chains, an alpha chain and a beta chain, linked by Hydrogen bonds and van der Waals forces. LH and FSH share nearly identical alpha chains, while the beta chain provides specificity for receptor interactions.
A third human gonadotropin is human chorionic gonadotropin (hCG), produced by the placenta during pregnancy.
MechanismGonadotropin receptors are embedded in the surface of the target cell membranes and coupled to the G-protein system. Signals triggered by binding to the receptor are relayed within the cells by the cyclic AMP second messenger system.
Gonadotropins are released under the control of gonadotropin-releasing hormone (GnRH) from the arcuate nucleus and preoptic area of the hypothalamus. The gonads — testes and ovaries — are the primary target organs for LH and FSH. The gonadotropins affect multiple cell types and elicit multiple responses from the target organs. As a simplified generalization, LH stimulates the Leydig cells of the testes and the theca cells of the ovaries to produce testosterone (and indirectly estradiol), while FSH stimulates the spermatogenic tissue of the testes and the granulosa cells of ovarian follicles.
DiseasesGonadotropin deficiency due to pituitary disease results in hypogonadism, which can lead to infertility. Treatment include administered gonadotropins, which therefore work as fertility medication. Such can either by produced by extraction and purification from urine or it can be produced by recombinant DNA.
Failure or loss of the gonads usually results in elevated levels of LH and FSH in the blood, since the pituitary gland tries to compensate for the insufficient gonads.
gonadotropin in German: Gonadotropine
gonadotropin in Spanish: Gonadotropina
gonadotropin in French: Gonadotrophine
gonadotropin in Italian: Gonadotropina
gonadotropin in Lithuanian: Gonadotropinai
gonadotropin in Japanese: 性腺刺激ホルモン
gonadotropin in Polish: Gonadotropiny
gonadotropin in Portuguese: Gonadotrofina
gonadotropin in Russian: Гонадотропные гормоны
gonadotropin in Simple English: Gonadotropin